Hot spot of fluoropyridine intermediates

At present, the quinolone antibiotics developed and put into mass production in China mainly include norfloxacin, ciprofloxacin, ofloxacin, enoxacin, lomefloxacin, fleroxacin, etc. Among them, the production of norfloxacin, ciprofloxacin and ofloxacin is the largest, accounting for 98% of the total production of fluoroquinolones in China.

Quinolones are generally synthesized from fluorobenzene ring to fluoroquinoline compound and then condensed with piperazine (or methylpiperazine). As China is rich in fluorite reserves, it is one of the countries with the largest output of fluorine-containing drugs and intermediates in the world, and more than 80% of fluorine-containing intermediates are supplied for export. On the whole, fluorobenzene intermediates developed earlier in China, and the current production capacity is generally surplus; The development of trifluoromethylene intermediates is late, and the development speed is fast in recent years; However, for heterocyclic aromatic compounds, especially fluoropyridines, only a few research units and manufacturers in China currently have the synthesis technology of fluoropyridine intermediates. Therefore, fluoropyridine intermediates will become one of the main research directions of domestic fluoropyridine intermediates in the next few years.