our country β-
After nearly 50 years of development, lactam antibiotics have formed a
complete production system. Almost all β- All lactam antibiotics (except
those within the patent period) can be produced in China, and the cost
is very low. Penicillin production ranks first in the world, and a large
number of them are exported to the international market; Cephalosporins
are basically self-sufficient, and some of them can be exported.
Currently,
and β- All the supporting intermediates of lactam antibiotics can be
produced by China itself. Except that the mother nuclei of semi
synthetic antibiotics, 7-ACA and 7-ADCA, need to be partly imported, all
the side chain intermediates can be produced and exported in large
quantities.
with β- As an example, phenylacetic acid, the main
supporting intermediate of lactam antibiotics, has nearly 30
phenylacetic acid manufacturers in China, with a total annual production
capacity of about 20000 tons. However, most enterprises are small in
scale, with the largest annual output of 2000 tons, and most others
produce hundreds of tons. In 2003, the total domestic demand for
phenylacetic acid was about 14000 tons, and the consumption structure
was: penicillin G accounted for 85%, other medicines accounted for 4%,
spices accounted for 7%, and pesticides and other fields accounted for
4%.
With the development of domestic spice, medicine, pesticide
and other industries, the demand for phenylacetic acid will further
increase. It is estimated that by 2005, the pharmaceutical industry in
China will consume about 14000 tons of phenylacetic acid, the pesticide
industry will consume 500 tons, and the spice industry will consume
about 2000 tons. In addition to the consumption in other fields, the
total domestic demand for phenylacetic acid is expected to reach 18000
tons in 2005.